Critical Limb Ischemia (CLI) is a serious health condition affecting the Lower Extremities. It is the most severe manifestation of Peripheral artery disease (PAD), a disorder that causes arteries to narrow or occlude. Diabetes, smoking, obesity and age are the most important risk factors contributing to CLI.
The primary goals of CLI treatment are limb salvage, pain relief, and improved wound healing1. Standard and preferred treatment options include revascularization which aims at improving blood flow to the affected limb. That can be achieved through either an endovascular technique (i.e. balloon angioplasty) or bypass surgery.
CLI is estimated to have an incidence of approximately 50 to 100 per 100,000 per year, and is associated with mortality rates as high as 20% at 6 months after onset1. Patients with CLI suffer from profound, chronic pain and will ultimately develop extensive tissue loss which can lead to major amputation (MA).